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| PharmaBlock Sciences (Nanjing), Inc. +86 400 025 5188 sales_china@pharmablock.com
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| Download the brochure on APPLICATION OF BICYCLO[1.1.1]PENTANES (BCP) AS BIOISOSTERES IN DRUG DISCOVERY Recently PharmaBlock was cited in C&EN news for its success with a series of molecules, including the kite-like structure- Bicyclo[1.1.1]pentane (BCP) ,which has been applied as bioisosteres of several different chemical structures. The newly- emerged bioisosteres with potential bioactivity is currently in large demand in drug R&D industry. Such moiety plays an important part in developing new drugs economically and effectively, as it can be applied to modifiy and optimize existing drug structures and equip them with better invitro and in vivo activity. As bioisosteres of several different chemical structures,Bicyclo [1.1.1] pentanes (BCP) has attracted more and more attention in drug R&D industry by virtue of its symmetrical and rigid rod- like stereochemical structure, better lipotrophy, increased electronegativity, among other physiochemical properties. |
