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PharmaBlock Whitepaper
Bridging molecules for innovative medicines

Indazole is important in at least three major areas in medicinal chemistry. a. It is a good bioisostere for phenol. Generally speaking, phenol’s heterocyclic bioisosteres, including indazoles, tend to be more lipophilic and less vulnerable to phase I and II metabolism in comparison to phenol itself. b. Indazole is a privileged fragment in FBDD. c. It has proven to be a privileged scaffold in scaffold hopping exercises, especially for protein kinase inhibitors.



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PharmaBlock Products - Indazoles
80,000+ building blocks, 63 series cover almost all the small molecule drugs R&D need
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