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PharmaBlock Sciences (Nanjing), Inc.     +86 400 025 5188   sales_china@pharmablock.com
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PharmaBlock Whitepaper
Bridging molecules for innovative medicines

Pyrrolidine motif on a drug may offer enhanced aqueous solubility and other physiochemical properties in addition to being part of the pharmacophore. The NH may serve as a hydrogen bond donor and, when its NH is masked, the N atom may serve as a hydrogen bond acceptor to its target protein. While pyrrolidine moiety appears frequently in drugs, it may have a potential liability of being bio-activated to the corresponding iminium ion and aminoaldehyde. These reactive metabolites have potential genotoxicity and mutagenicity. While this is not prevalent, it is always a good idea to be vigilant.


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PharmaBlock Products——Pyrrolidine Derivatives
80,000+ building blocks, 63 series cover almost all the small molecule drugs R&D need
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Tel: +86-400 025 5188
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E-mail: sales@pharmablock.com