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PharmaBlock Whitepaper
Bridging molecules for innovative medicines

Bicyclo[3.1.0]hexanes are conformationally restrained isosteres for cyclohexanes, but with no increase in molecular weight and only a modest elevation in lipophilicity.They may confer tighter binding to the target protein, more resistance to metabolism, and often provide better selectivity, resulting in less off-target effects.



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PharmaBlock Products - Bicyclo[3.1.0]hexanes
80,000+ building blocks, 63 series cover almost all the small molecule drugs R&D need
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