| Pyrrolotriazines and imidazolotriazines are bioisosteres for bases such as adenine, guanine, purine, etc. As a consequence, they have found utility in the fields of nucleoside antiviral drugs, kinase inhibitors, PDE, and HDAC inhibitors.
Key Points - Apply in nucleoside antiviral drugs and kinase inhibitors.
- Good bioisosteres of the adenine portion of ATP.
- Pyrrolotriazine-containing drugs contribute to the treatment of COVID-19.
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