【Whitepaper】Spirocyclic pyrrolidines in Drug Discovery

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Bridging molecules for innovative medicines

Spirocyclic pyrrolidines combine the characteristics of both pyrrolidines and spirocycles. The pyrrolidine motif on a drug may also offer enhanced aqueous solubility and otherphysio chemical properties. Meanwhile, spirocyclic pyrrolidines, likemost spirocycles, are bestowed with the three advantages over their flatcounterparts: (a) inherent three-dimensional geometry offers tighter interactions with the target protein thus more potent and selective with feweroff-target effects; (b) potential superior physiochemical properties; and (c)possible novel intellectual properties.

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PharmaBlock Products - Spirocyclic pyrrolidines
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