Tetrahydropyrans in Drug Discovery In summary, THP is a rigid form of linear ether, thus has lower entropy. As a bioisostere of cyclohexane,THP may gain an additional point of contact with the target by offering oxygenas a hydrogen bond acceptor. In medicinal chemistry, THP substituents, with lower lipophilicity in comparison to the cyclohexyl isosteres, have been employed to modulate the pKa of drugs and improve their absorption, distribution, metabolism, and excretion(ADME).
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