【Whitepaper】Spirooxetanes in Drug Discovery

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Spirooxetanes combine the characteristics of both oxetanes and spirocycles. The oxygen atom on the oxetane may serve as a hydrogen bond acceptor, interacting with the target protein. The oxetane motif on a drug may also offer enhanced aqueous solubility and other physiochemical properties.Meanwhile, spirooxetanes, like most spirocycles, are bestowed with a trio of advantages: (a) More extensive interactions with target proteins; (b) more favorable physiochemical properties; and (c) potential novel intellectual properties.

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